Sildenafil Citrate is a medication used to deal with Erectile Dysfunction in men. Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, Sildenafil works by increasing blood flow to the penis to help a man get and keep an erection.
Compounded Sildenafil Citrate comes in preparations of 25mg, 50mg, and 100mg. Initial dosages will usually be for 50mg. At this dose, you and your doctor can monitor your physical reaction to the medicine and address any side effects early on. If 50mg is very effective the dose can be reduced to 25mg. But, if well tolerated and only mediocre results are reported, men have then often upgraded to Sildenafil 100 mg.
Given below are some of the benefits of Sildenafil Citrate:
• Mode of Action. Sildenafil and other Phosphodiesterase types 5 (PDE5) drugs work by increasing blood flow to the penis. Though the 100mg effects do not last longer than a lower dosage, the higher concentration does have a more profound effect. However, it is not a good idea to use a higher strength tablet than you really need. Side effects are more likely at higher doses.
• Satisfaction with treatment. Naturally, a stronger tablet has a better chance of achieving desired results – achieving and maintaining an erection hard enough for sexual intercourse. This, in turn, results in not only physical but emotional satisfaction, helping couples in their relationships and improving the man’s self-esteem.
• Reduced anxiety. A number of factors go into the success of an ED medication. This uncertainty can lead to a great deal of anxiety for couples who have already had to deal with the frustration of erectile dysfunction – not knowing if they should again get their hopes up for a successful sexual encounter only to be disappointed. The higher dose can, therefore, have a positive psychological effect, helping men and their partners to feel more confident about having sex.
• Efficacy – Sildenafil remains a popular choice for men experiencing erectile difficulties because it is a highly effective medication. Most dosages have shown in clinical trials to provide positive erection results suitable for sexual intercourse (63 percent, 74 percent, and 82 percent respectively).
• Minimal side effects. All drugs have the potential to cause side effects and Sildenafil is no different. In general PDE-5 inhibitors such as Viagra are well tolerated. Years of clinical studies and trials have revealed Viagra to be a safe drug which is only likely to provoke mild to moderate side effects in a small proportion of its users. To definitively quantify the side effects of one ED medication next to another is tricky, as every patient is different. Muscle pain is listed as a common side effect (presenting in 1 to 10 out of 100 people) in the patient information leaflet for Cialis. In the leaflet for Viagra, muscle pain is listed as an uncommon side effect (presenting in up to 1 in 100 people).
Tadalafil is a popular ED drug and is particularly noted for its lengthy 17.5-hour half-life and subsequent duration of function; which is up to 36 hours. This characteristic has earned Tadalafil the moniker ‘the weekend pill’, as once the patient has taken a dose, the drug remains active for a whole day and a half. So, for instance, a dose taken on Friday evening may still be functional all the way up to Sunday morning. Contrary to what some might think, however, this does not mean that an erection will be present for the whole duration of action; rather that the user will be able to achieve an erection when sexually stimulated during the time that Tadalafil is working. Other oral tablet medicines may only remain active for four to six hours. Topical agents and urethral suppositories, although they get to work within minutes, may only have an effect which lasts for one or two hours.
Given below are some of the benefits of Tadalafil:
• Tadalafil and even more so of Tadalafil daily, is that it allows the user to be spontaneous.
• Tadalafil takes 30-60 minutes to work, but after this is functional for up to 36 hours. That means that once the treatment has begun to work, the user does not have to interrupt foreplay in order to take a pill, or apply a device or topical agent; once sexually stimulated, they’re ‘ready to go’.Furthermore, those who take Tadalafil Daily, which contains a smaller dose but is designed to be taken once a day, do not have to wait 30-60 minutes for the tablet to work. This medicine remains functional 24 hours a day and is suitable for those men who plan to have sex three (or more) times over the course of a week.
• Some may see taking a tablet every day as a minor drawback, whereas others may prefer doing so and incorporating ED treatment into their routine.
• Because it doesn’t require ‘on-demand’ administration, Tadalafil daily is considered by many to be the closest of all ED medications currently on the market to being an ‘instant’ treatment.
• Cialis performs strongly among its competitors in terms of efficacy. There are two doses of Cialis available (10 and 20mg), and two doses of Cialis Daily (2.5mg and 5mg). As one would expect, these different doses have reported different efficacy rates in clinical trials: In one study[2], 10mg and 20mg doses of Cialis resulted in erections potent enough for vaginal penetration in 73 and 81 percent of cases respectively; and resulted in erections strong enough to complete intercourse in 59 and 71 percent of cases respectively.
Vardenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, vardenafil works by increasing blood flow to the penis to help a man get and keep an erection. Vardenafil becomes effective within 25 minutes to an hour of taking the tablet and then continues to work for a period of four to five hours. This does not mean that you will have an erection for this entire duration, but you will get an erection when aroused by sexual stimulation.
• Vardenafil is taken on demand; you can simply take Vardenafil shortly before sexual activity as you need to. You should not take more than one Vardenafil troche in the course of a day.
• Vardenafil remains effective if taken immediately after a meal, though a meal high in fat may cause the effects to be delayed.
• Vardenafil produces effective results in the majority of men that use it. In clinical trials, between 68% and 80% of participants were able to achieve penetration, depending on their dosage. Between 53% and 65% of participants found they were able to maintain an erection.
• The most common side effect experienced with Vardenafil is a headache, reported in up to one in ten users. Up to one in 100 people experience a blocked nose, indigestion, flushing, or feeling dizzy.
• During the consultation for Vardenafil, a doctor will take into account any other medicines you are taking and any pre-existing health conditions.
• The 10 mg dose of Levitra is the only ED pill available as an orodispersible tablet, which can be placed on the tongue to melt in the mouth. This enables Levitra to be taken in a discreet manner, without a glass of water. Less than 1 in 100 people who take Levitra experience serious side effects. Levitra is produced by Bayer, a well-known multinational pharmaceutical company. Before it was licensed across Europe in 2003, it was subject to testing in clinical trials. Since being launched, Levitra has joined Viagra and Cialis in becoming a popular form of medication for erectile dysfunction. The smallest available dose of Levitra is 5mg. Because it is available in smaller doses than other forms of ED medication, Levitra may in some cases be issued to older patients or those with underlying health conditions who may not be able to use other tablets.
ApomorphineSublingual apomorphine for the treatment of erectile dysfunction. Erectile dysfunction (ED) is a prevalent problem in the world and wreaks havoc on the psychosocial well-being of sufferers as well as partners. First-line treatment for ED is oral therapy, however, the currently available oral erectogenic agent is not uniformly successful and requires approximately 1 h to exert its effect.
Apomorphine is a novel, oral erectogenic agent taken sublingually. It exerts its effect on hypothalamic centers involved in the triggering of the erection cascade. It dissolves rapidly and results in an erection in responders in approximately 20 min. By avoiding first-pass metabolism through its sublingual administration, apomorphine avoids any significant interaction with food or other drugs. In trials in over 4000 subjects representative of the general ED population, beneficial effects were seen in a significant percentage of men. Its exact position in the market remains to be seen, however, its ability to permit spontaneous sexual relations will prove to be of significant benefit to many men.